|
KMID : 0861020110260020059
|
|
Korea Journal of Herbology
2011 Volume.26 No. 2 p.59 ~ p.66
|
|
|
Effects of Mixture of Lycii Radicis Cortex and Moutan Cortex on Corticotropin-Releasing Factor, c-Fos, and Tyrosine Hydroxylase in Forced Swimming Test
|
|
Sim Eun-Yeong
Lee Tae-Hee
|
|
|
Abstract
|
|
|
Objectives:The goal of this study was to investigate the antidepressant effects of Mixture of Lycii Radicis Cortex and Moutan Cortex on the change of HPA-Axis and Catecholamic system.
Methods: We were performed the Forced Swimming Test. The expressions of Corticotropin-Releasing Factor (CRF) and c-Fos at paraventricular nucleus (PVN), and tyrosine hydroxylase (TH) at ventral tegmental area (VTA) and locus coeruleus (LC) were evaluated by immunohistochemical method.
Results: The duration of immobility in the Forced Swimming Test was significantly decreased in A100, A400(p<0.05~p<0.01). CRF expressions at PVN was significantly decreased in A400(p<0.05).No other group showed significant difference in expression of c-Fos at PVN comparing with control group. TH expressions at VTA was significantly decreased in A100 and A400, respectively(p<0.001). TH expressions at LC was significantly decreased in A100(p<0.01).
Conclusions :According to the above results, Mixture of Lycii Radicis Cortex and Moutan Cortex has antidepressant effects via the reduction of CRF expression and the Catecholamine System activity.
|
|
|
KEYWORD
|
|
|
Lycii Radicis Cortex, Moutan Cortex, FST, CRF, c-Fos, PVN, TH, VTA, LC
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|
|